ea0011p842 | Thyroid | ECE2006
Fountoulakis S
, Kolaitis N
, Philippou G
, Vartholomatos G
, Tsatsoulis A
Introduction-objective: Fas-mediated thyroid cell apoptosis is differentially regulated in autoimmune thyroid disease (AITD) being up-regulated in Hashimotos thyroiditis (HT) and down-regulated in Graves disease (GD). The soluble form of Fas (sFas), lacking the transmembrane domain due to alternative splicing may inhibit apoptosis by binding to Fas ligand. In this preliminary study we examined whether sFas is also differentially expressed in patients with AITD....